If you’re craving a heartwarming dish that feels like a warm hug on a chilly evening, this Chicken Butternut Squash Casserole Recipe is exactly what you need. It perfectly combines tender shredded chicken with sweet, roasted butternut squash and a creamy, cheesy sauce that bakes into bubbly golden goodness. Whether you’re looking for a comforting weeknight dinner or a crowd-pleaser for family gatherings, this casserole brings flavors, textures, and autumn vibes all in one dish.

Ingredients You’ll Need

The image shows seven white bowls and containers arranged on a white marbled surface. One bowl holds small pieces of raw chicken with pale pink color and smooth texture on the left. Another bowl near the top contains bright orange cubed sweet potatoes with a rough but firm texture. In the center is a small onion with golden brown, papery skin. To the right of the onion, a white spoon with a heaping scoop of white flour rests on the surface. Below the chicken bowl is a small white bowl filled with pale white breadcrumbs with a fine, crumbly texture. Next to it is a white bowl with white sour cream, smooth and creamy. A single brown egg with a smooth shell lies between these ingredients. To the right side at the bottom is a block of beige tofu with a firm, smooth surface. Finally, a clear glass bowl contains a rectangular block of white cream cheese with a soft, slightly crumbly texture. photo taken with an iphone --ar 4:5 --v 7

Each ingredient in this Chicken Butternut Squash Casserole Recipe plays an essential role in building its rich flavor and satisfying texture—simple staples that come together to create a dish that’s both nutritious and delicious.

2 cups cubed butternut squash: Roasts to tender sweetness, giving the casserole its signature fall flavor and bright color.
1 lb cooked chicken, shredded: Adds protein and a savory balance to the sweetness of the squash.
1 cup cooked rice or quinoa: Provides a hearty base to soak up all the creamy sauce.
1 cup milk or cream: Creates a luscious, velvety sauce that binds everything together.
½ cup sour cream: Adds tangy richness to elevate the flavor depth.
1 cup shredded cheddar cheese: Melts into gooey topping and enriching layers.
½ tsp thyme: Infuses a subtle earthy aroma that complements the chicken.
½ tsp garlic powder: Adds a mild, savory kick without overpowering the dish.
Salt & pepper to taste: Essential for balancing and enhancing all the flavors.

How to Make Chicken Butternut Squash Casserole Recipe

Step 1: Roast the Butternut Squash

First things first, preheat your oven to 375 degrees Fahrenheit (190 degrees Celsius). Spread the cubed butternut squash on a baking sheet and roast it for about 20 minutes, or until the cubes are fork-tender. This roasting step caramelizes the squash’s natural sugars, unlocking the sweet, nutty flavor that makes the casserole so irresistible.

Step 2: Prepare the Casserole Mixture

While the squash is roasting, combine the shredded cooked chicken, cooked rice or quinoa, milk or cream, sour cream, thyme, garlic powder, and half of the shredded cheddar cheese in a large bowl. Season with salt and pepper to your liking. Once the squash is roasted, gently fold it into the mixture, making sure every bite will have a perfect balance of creaminess and roasted sweetness.

Step 3: Assemble and Bake

Transfer your flavorful mixture into a greased casserole dish. Evenly sprinkle the remaining cheddar cheese on top, creating a delicious cheesy crust. Bake in the preheated oven for about 25 minutes, or until the cheese is melted, bubbly, and slightly golden on top. This baking step melds all the layers together and ensures each spoonful is warm and comforting.

How to Serve Chicken Butternut Squash Casserole Recipe

A white plate holds a serving of a mixed dish with three main layers: large bright orange chunks of cooked squash scattered across the plate, a layer of light tan quinoa mixed throughout, and dark green wilted kale spread evenly underneath and between the other layers. There is a single fresh green bay leaf placed on top as garnish. A silver fork is resting on the right side of the plate. The plate sits on a white marbled surface with a white cloth partially visible on the left side. Photo taken with an iphone --ar 4:5 --v 7

Garnishes

Fresh garnishes can brighten up this hearty dish beautifully. Consider sprinkling chopped fresh parsley or thyme leaves over the top before serving – their vibrant green color will contrast wonderfully with the golden casserole. A light drizzle of balsamic glaze can add a subtle tang that complements the sweetness of the butternut squash nicely.

Side Dishes

Since the Chicken Butternut Squash Casserole Recipe is so filling, lighter side dishes work best. A crisp green salad with a citrus vinaigrette or roasted Brussels sprouts with a touch of garlic provide a fresh, crunchy counterpoint. Steamed green beans or a simple coleslaw also nicely balance out the creamy richness of the casserole.

Creative Ways to Present

Want to impress your guests? Serve the casserole in individual ramekins for a personalized touch. You can also layer the ingredients in a clear glass baking dish or trifle bowl so the beautiful layers are visible. For a fun twist, scoop the casserole into hollowed-out mini pumpkins for a festive fall presentation that is as charming as it is delicious.

Make Ahead and Storage

Storing Leftovers

Leftover Chicken Butternut Squash Casserole Recipe keeps beautifully in the fridge for up to 3 days. Store it in an airtight container to prevent it from drying out. You can enjoy it cold or warm it up for a comforting quick meal the next day.

Freezing

This casserole freezes wonderfully, making it ideal for meal prep. Cool the casserole completely, then cover tightly with plastic wrap and foil before placing it in the freezer. It will stay fresh for up to 2 months. When you’re ready to eat, thaw overnight in the fridge for best results.

Reheating

To reheat, warm individual portions in the microwave or place the thawed casserole back into an oven-safe dish, covering lightly with foil. Heat at 350 degrees Fahrenheit (175 degrees Celsius) for about 15-20 minutes or until warmed through. Remove the foil in the last few minutes if you want to refresh the cheesy topping’s golden crust.

FAQs

Can I use fresh chicken instead of cooked chicken?

Yes, but you’ll need to cook and shred the chicken before mixing it into the casserole. Poaching or roasting chicken breasts until fully cooked then shredding works perfectly and keeps the casserole moist and flavorful.

Is there a gluten-free option for this Chicken Butternut Squash Casserole Recipe?

Absolutely! Using rice or quinoa and ensuring your sour cream and other ingredients are gluten-free makes this casserole naturally gluten-free and safe for those with dietary restrictions.

Can I substitute sweet potatoes for the butternut squash?

Yes! Sweet potatoes offer a similar sweetness and texture, making for a delicious variation that’s just as cozy and comforting.

What can I add for extra vegetables?

Chopped spinach, kale, or even sautéed mushrooms can add color and nutrition. Adding them is a great way to customize the dish and add your favorite greens.

How do I make the casserole creamier?

If you prefer an extra creamy texture, increase the milk or cream slightly or add a little cream cheese. Mixing these into the base will enrich the sauce without overpowering the other flavors.

Final Thoughts

This Chicken Butternut Squash Casserole Recipe is one of those comforting dishes you’ll find yourself making again and again. With its perfect blend of sweet, savory, creamy, and cheesy, it feels like home on a plate. If you want a simple yet standout meal that warms your soul, don’t hesitate to give this recipe a try—you won’t be disappointed!